Colo-Risk™ (in development)
Indication for use:
Adults with a family history of Colorectal Cancer or other risk factors for Colorectal Cancer such as a
body mass index (BMI) >30 and/or history of smoking and all patients over the age of 50. (more)
Intended Use:
Colo Risk™ determines a person's genetic predisposition to Colorectal Cancer and combines these genetic results with environmental
risk factors to provide a person's life-time risk of developing Colorectal Cancer. Patients can then be cost-effectively stratified for
follow on surveillance (screening), education and disease management programs.
Test Design:
The test looks at 10 Single Nucleotide Polymorphisms (SNPs) and in a weighted algorithm combine the results of this genetic test with
environmental factors such as age, BMI and smoking in a calculation to determine a person's lifetime risk of developing Colorectal
Cancer.
Some of the specific genes and polymorphisms identified include:
| Polymorphism | Gene/Location | Licensor |
|---|---|---|
| rs12953717 | SMAD7 / 18q21 | Cancer Care Ontario |
| rs4939827 | SMAD7 / 18q21 | Cancer Care Ontario |
| rs4464148 | SMAD7 / 18q21 | Cancer Care Ontario |
| rs3802842 | 11q23 | Cancer Care Ontario |
| rs7014346 | 8q24 | Cancer Care Ontario |
| rs719725 | 9p24 | Cancer Care Ontario |
